Selborne College beat Grens 38-5, while there were also wins for Dale College and Kirkwood.
The hosts dedicated their emphatic home win to coach Phiwe Nomlomo, who is leaving the school for a coaching post at Saru.
In other matches involving Eastern Cape schools, Dale College thumped Stirling 60-12, while Kirkwood edged Despatch 10-3.
Eastern Cape schools results:
Stirling 12 Dale College 60
Selborne 38 Grens 5
Despatch 3 Kirkwood 10
Photo: Selborne College